Neuropsychopharmacology Podcast

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Episodes

Date Title & Description Contributors
2024-05-06

  Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial

There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the need to search for food. But neurological studies have suggested that ghrelin might also play a role in compuls...
2024-03-05

  Spotlighting SHAPERS: Sex hormones associated with psychological and endocrine roles

Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper in the journal Neuropsychopharmacology, called “Spotlighting SHAPERS: sex hormones associated with psychologica...
2024-01-04

  Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making

Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role in cognitive flexibility. That is, serotonin levels are related to the fact that someone is perseverating on int...
2023-10-16

  Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl

The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is appearing on the streets adulterated with a drug called xylazine. Justin Strickland, assistant professor at Joh...
2023-09-06

  The why, when, where, how, and so what of so-called rapidly acting antidepressants

Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Program. He’s one of the two authors of a recent review paper in the journal Neuropsychopharmacology, “The why, when, ...
2023-06-23

  AI-based analysis of social media language predicts addiction treatment dropout at 90 days

In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of people who enter drop out within the first month. There hasn’t been a highly accurate method of identifying who m...
2023-04-21

  Oxytocin effects on amygdala reactivity to angry faces in males and females with ASPD

Antisocial personality disorder, or ASPD, is a difficult disorder to study. There have been studies on psychopathic individuals, and on youth with psychopathic traits, but most studies on ASPD to date have been on incarcerated adults. A team of researc...
2023-02-22

  To dismantle structural racism in science, scientists need to learn how it works

It’s clear there are diversity issues in science, both in terms of who does or doesn’t receive research grants, as well as who is or isn’t represented at the highest levels of scientific research. When Caleb Weinreb and Daphne Sun began their PhD progr...
2022-12-22

  Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity

Psychedelic drugs have received attention recently for their potential use as treatments for psychiatric disorders. Single, high doses of LSD have shown promise for treating depressive disorders. But there’s another way in which people have been using ...
2022-11-01

  Sex-dependent risk factors for PTSD: a prospective structural MRI study

After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance, perhaps women had more cumulative trauma in t...