In this OA Week episode, Elizabeth Seiver speaks with James Fraser, Associate Professor at UCSF in the Department of Bioengineering and Therapeutic Sciences and a founding member of ASAPbio, about the scientist-driven mission to promote the use of preprints in the life sciences. The conversation covers the history of ASAPBio; the advantages of posting manuscripts to a preprint server; the impact preprints have on science journalism; and the relationship between Open Access and preprints.