In this second Evidence-Based Medicine podcast, Associate Editor Terrence Shaneyfelt interviews Salim Virani, from the Health Services Research and Development, Houston, USA. Professor Virani is the leading author of the systematic review with meta analysis, "Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding". Read the article here: http://ebm.bmj.com/content/early/2016/10/25/ebmed-2016-110531.extract.