Host: Brian P. McDonough, MD, FAAFP As an unforgivingly cold, frigid winter in America has led to the explosive release of tree pollens over a short period this spring, seasonal allergies have returned with a vengeance. Says, Dr Mitchell Gaynor, clinical assistant professor of medicine at Weill Cornell Medical College in New York City, this could make for one of the worst allergy seasons of all time. How can primary care providers ready themselves on the frontlines of this mass allergy assault? Dr. Brian McDonough and Dr. Gaynor discuss strategies to keep clinicians on top of this emerging threat, including new understandings of eco-genetic mechanisms of allergic disease.