One of the most pressing problems in transplant medicine is the shortage of available organ donors to keep up with high demand. What are the ethical considerations of solving the liver shortage problem with xenotransplantation? Host Dr. Aaron Carroll welcomes Drs. Tector and Helft for the second part in a discussion of xenotransplantation. Dr. Joseph Tector directs the section of transplant surgery's xenotransplantation research program at Indiana University Health. Dr. Paul Helft is director of the Charles Warren Fairbanks Center for Medical Ethics at Indiana University Health, and is a member of the IU Health Ethics Committee and co-chair of the IU Health Ethics Consultation Subcommittee.