As the nation’s opioid epidemic has now become a deadlier drug overdose epidemic, the AMA Opioid Task Force urges individualized and evidence-based patient care for those with a substance use disorder. Offering their unique perspectives on how to help patients, physician members of the AMA Opioid Task Force shared their perspectives on helping patients with a substance use disorder. Drs. Patrice Harris, Frank Dowling, Elizabeth Salisbury-Afshar, Sharon Levy, and John Renner.