The Clark Family Story: Tracing the Cause ofHemophiliaby Jeffrey T. Bradley Ann Arbor Skyline High SchoolHealth& Medicine MagnetIn collaboration with the Centers for Disease Control and Prevention Jeffrey T. Bradley CDC Science Ambassador Program , Ann Arbor Skyline Health& Medicine Magnet, www.SkylineHealthMedicine.comThis lesson emphasizes the relationship between DNA sequences, mutations in DNA and the change in the resulting protein structure and function. Hemophilia A will be used as a real life example of how a mutation in DNA results in a change in a protein’s structure and resulting ability to function. In order to complete these activities, the students should have prior knowledge in DNA structure and mutations, protein synthesis, Mendelian genetics and sex-linked traits.Learning Outcomes• The student will be able to relate a DNA sequences to the resulting protein structure in the factor VIII gene.• The student will be able to demonstrate the use of restriction enzymes in the identification of a specific DNA sequence and explain how this can be used to diagnosis someone has having the hemophilia factor VIII mutation.• The student will be able to demonstrate how a protein’s structure and function can change with a change in the factor VIII DNA sequence (mutation).• The student will be able to explain the genetics of hemophilia inheritance and affect on the blood clotting process.• The student will be able to draw conclusions about the risk of passing on the mutated gene.
The Clark Family Story: Tracing the Cause of Hemophilia by Jeffrey T. Bradley Ann Arbor Skyline High School Health& Medicine Magnet In collaboration with the Centers for Disease Control and Prevention Jeffrey T. Bradley CDC Science Ambassador Program , Ann Arbor Skyline Health& Medicine Magnet, www.SkylineHealthMedicine.com This lesson emphasizes the relationship between DNA sequences, mutations in DNA and the change in the resulting protein structure and function. Hemophilia A will be used as a real life example of how a mutation in DNA results in a change in a protein’s structure and resulting ability to function. In order to complete these activities, the students should have prior knowledge in DNA structure and mutations, protein synthesis, Mendelian genetics and sex-linked traits. Learning Outcomes • The student will be able to relate a DNA sequences to the resulting protein structure in the factor VIII gene. • The student will be able to demonstrate the use of restriction enzymes in the identification of a specific DNA sequence and explain how this can be used to diagnosis someone has having the hemophilia factor VIII mutation. • The student will be able to demonstrate how a protein’s structure and function can change with a change in the factor VIII DNA sequence (mutation). • The student will be able to explain the genetics of hemophilia inheritance and affect on the blood clotting process. • The student will be able to draw conclusions about the risk of passing on the mutated gene.