Overview: This podcast will explore the utility of whole genome sequencing (WGS) in the context of hospital epidemiology of infection prevention, including recent evidence showcasing success in identifying and/or determining the nidus of a cluster or outbreak. The speakers will explain how they have or are planning to use WGS and the interplay between those performing or studying WGS and clinicians/infection prevention staff. Advantages, challenges, limitations, and research gaps will be addressed as well as what the speakers envision for the future. Speakers: Deena R. Altman, MD, MS Alexander Sundermann, DrPH, CIC, FAPIC Chad Nix, MSc, CIC (moderator)