In this Tech Blast episode, BioTechniques' Digital Editor, Annie Coulson, discusses single domain antibodies with ProSci’s Andy Lee, Lead Scientist of the Single Domain Antibody Program, and David Eling, Director of Business Development. Andy and David describe what single domain antibodies (sdAbs) are, including their unique characteristics, such as their small size. They then go on to explore the applications of sdAbs, from increasing resolution in imaging studies, to developing antidotes for snake venom. Listen to this episode to get an overview of sdAbs, how they could be incorporated into your research and their link to llamas. Contents: Introductions: 00:00–01:25 What are single domain antibodies? 01:25–3:05 Applications of single domain antibodies: 03:05–05:05 Unique characteristics of sdAbs: 05:05–07:55 sdAbs for SARS-CoV-2: 07:55–08:35 sdAbs for therapeutics and diagnostics: 08:35–11:25 Unique applications, including biosensors and animal feed: 11:25–12:50 Working with researchers to develop sdAbs: 12:50–13:25 The future of sdAbs: 13:25–15:50 Closing remarks: 15:50–16:20