Complex Cases in Kidney Stone Disease CME Available: https://auau.auanet.org/node/41889 At the conclusion of this activity, participants will be able to: 1. Describe the pathophysiology, genetic basis, and clinical presentation of Primary Hyperoxaluria Type 1. 2. Analyze the unique considerations and challenges in evaluating kidney stones in pediatric patients. 3. Utilize the results of 24-hour urine testing to guide dietary and pharmacologic interventions for stone prevention. 4. Recognize the indications for genetic testing in patients with kidney stones and utilize the results to inform diagnosis and treatment. 5. Employ appropriate patient management and family counseling strategies in consideration of the impact of genetic testing results. 6. Properly refer patients with kidney stone disease to a nephrologist when warranted. ACKNOWLEDGEMENTS: Support provided by an independent educational grant from: Alnylam Pharmaceuticals, Inc.