Editor in Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Priyesh N. Patel, MD, and Associate Editor Peter M. Vila, MD, MSPH, to discuss the role of the operating room and its necessity in treating skin cancer defects as outlined in the paper “Cost-Effectiveness Analysis of Operating Room and In-Office Reconstruction of Skin Cancer Defects” which published in the December 2024 issue of Otolaryngology–Head and Neck Surgery. They weigh the effects of operating room on efficiency, patient satisfaction, and procedure success.