Dave Asprey and Dr. Sandra Kaufmann explore the 2025 Biohacking State of the Union, sharing cutting-edge strategies and practical tools to enhance health, longevity, and vitality.
What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?Â
Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.Â
From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.Â
What You’ll Learn:Â
• The Seven Tenets of Aging and how they’ll change your approach to healthÂ
• Why indulging in “bad” habits doesn’t have to sabotage your longevityÂ
• Biochemical secrets to combat oxidative stress, glycation, and cellular junkÂ
• The real story behind NAD, circadian rhythms, and the tools for better sleepÂ
• How to create a personalized health plan that’s sustainable, effective—and funÂ
Resources:Â Â
• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025Â
• Kaufmann Protocol Website: https://kaufmannprotocol.comÂ
• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047Â
• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=enÂ
• Danger Coffee: https://dangercoffee.comÂ
• Dave Asprey’s Website: https://daveasprey.comÂ
• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/booksÂ
• Dave Asprey’s Linktree: https://linktr.ee/daveaspreyÂ
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.comÂ
• Own an Upgrade Labs: https://ownanupgradelabs.comÂ
• Upgrade Labs: https://upgradelabs.comÂ
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.comÂ
 SPONSORS: Â
Leela Quantum | Head to https://leelaq.com/DAVE for 10% off.Â
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.Â
Timestamps:Â
• 00:00 TrailerÂ
• 00:45 Guest IntroductionÂ
• 02:30 Longevity InsightsÂ
• 04:22 Personal StoriesÂ
• 08:00 PharmaceuticalsÂ
• 12:26 Diet and LifestyleÂ
• 18:19 Seven TenetsÂ
• 22:04 Sleep and Circadian RhythmsÂ
• 26:41 NAD and SupplementsÂ
• 37:46 Blood Sugar and AGEsÂ
• 47:09 MicrocirculationÂ
• 49:08 NRS and ImportsÂ
• 49:18 Celebrex MedicationÂ
• 50:03 Celebrex BenefitsÂ
• 50:41 Alzheimer’s and CelebrexÂ
• 51:28 AntioxidantsÂ
• 54:26 Stem Cells and ExosomesÂ
• 58:03 Laser Skin TreatmentsÂ
• 01:07:34 Hormones and LongevityÂ
• 01:20:03 Lithium for MoodÂ
• 01:27:45 Gender and LongevityÂ
• 01:32:39 Final ThoughtsÂ
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